A 55-year-old woman presents complaining of increased urination for the past eight months. On physical examination, she has a reduced sensation to touch and vibration in both feet and ankles. Blood tests reveal a plasma glucose level of 232 mg/dL. Her fasting glucose plasma level is 170 mg/dL. She is diagnosed with the condition that is characterized by a decreased sensitivity of target tissues to insulin. The organ that produces this hormone also secretes which of the following hormones?

1.Leptin
2.Renin
3.Cortisol
4.Ghrelin

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