Which of the following immunostains can aid in the differentiation between a reactive mesothelial cells and mesothelioma?

1. BAP1
2. BerEP4
3. Calretinin
4. D2-40
5. MOC31

ANswer is BAP 1 -  Below is an extremely important table for Lung Tumours 

• 	Mesothelioma	Reactive mesothelial cells
  BAP1	Lost (60% of cases)	Retained
  MTAP	Lost	Retained
  EMA (E29 clone)	Strong membranous	Cytoplasmic / weak membranous
  Desmin	Negative	Positive

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