Pathogenesis of parvovirus infections

• After infecting rapidly dividing erythrocyte precursors, such as bone marrow cells, foetal liver erythroid cells, and erythroid leukaemia cells, the virus kills these cells, causing PRCA
• The infection of blood vessel endothelial cells causes erythema infectiosum.
• It has been proven that the B19 virus initially enters the body via the nasopharynx or upper respiratory tract before spreading to the blood and causing viremia.
• The infection is subsequently established when the virus infects mitotically active erythroid precursor cells in the bone marrow.
• The virus penetrates susceptible cells via the P blood antigen receptors on the progenitors of erythrocytes.
• The virus enters the nucleus of red cells, begins to replicate, and then kills the red cells.
• Due to the viruses’ destruction of erythroid precursor cells, the formation of RBCs is halted for roughly one week.

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