P57 and Molar pregnancy

• The differential diagnosis between nonmolar products of conception (POC) and complete and incomplete moles is now aided by immunohistochemistry for p57 
• P57 is a paternally imprinted maternally expressed gene. Therefore, its expression is lacking in trophoblasts and stromal cells of complete moles, which do not have maternal genes.
• On the other hand, incomplete and nonmolar POCs show p57 expression.
• Immunohistochemistry for p57 is therefore the first test to distinguish between complete mole and nonmolar specimens or incomplete moles.

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