Airway remodelling in Asthma

• Thickening of airway wall
• Sub–basement membrane fibrosis (due to deposition of type I and III collagens)
• Increased vascularity
• Increase in the size of the submucosal glands and number of airway goblet cells
• Hypertrophy and/or hyperplasia of the bronchial wall muscle with increased extracellular matrix

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