A 65-year-old woman presents to the hospital with complaints of fatigue and abdominal cramps. She has been suffering from diabetes mellitus and hypertension. On examination, she looks slightly pale and depressed. On abdominal examination, there is hepatomegaly, and a 13-cm spleen is palpable below the left costal margin. Laboratory investigations reveal, hemoglobin 8.8 g/dl, platelets 6000000 per microliter, and white cell count 160000 per microliter. Her neutrophil alkaline phosphatase is less than 400 which is normal, and peripheral smear shows the left shift with promyelocytes, myelocytes, and metamyelocytes. Further investigations reveal T315I mutation. What is the most appropriate treatment in this case?

1.Imatinib
2.Nilotinib
3.Dasatinib
4.Ponatinib

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