Question Contributed by Dr. Bala. 

A teenager comes to the emergency room looking quite ill. Emergency medical services report that this appears to be a suicide attempt using rat poison. The patient is in hypovolemic shock from profuse vomiting and diarrhea. You note the strong smell of garlic from the patient. Which one of the following correctly describes an action of this toxin?

a It inhibits pyruvate dehydrogenase.

b It activates pyruvate dehydrogenase.

c It reduces the concentration of pyruvate.

d It increases glutathione production.

Yesterdays answer -  This infant has septo-optic dysplasia (also known as de Morsier syndrome), a condition characterized by absence of the septum pellucidum, optic nerve hypoplasia, and abnormalities of the hypothalamic–pituitary axis with resultant endocrine dysfunction.

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