Giant cell tumour

• Spindle and round / oval mononuclear cells also present (macrophage-like and primitive mesenchymal cells with poorly defined cytoplasm and mitotic activity which are the neoplastic cells)
• Highly vascular stroma; may have fibrosis or reactive woven bone (common)
• Numerous osteoclast-like giant cells uniformly distributed throughout tumor; many giant cells are larger than normal osteoclasts with numerous (> 50) nuclei; some areas may have a paucity of giant cells

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