A pathologist examining a tissue sample observed signs of cell death. She wants to determine if the mechanism of apoptosis is via the intrinsic or extrinsic pathway. Apoptosis is regulated by which gene?

1.TP53 gene via regulation of the BCL2 gene
2.TP53 gene via regulation of the BAX gene
3.APAF1 gene via regulation of the BCL2 gene
4.APAF1 gene via regulation of the BAX gene

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