A 65-year-old patient is brought with slowly progressive swelling in the submandibular region. The lesion is firm, poorly circumscribed, and unencapsulated. The histology following the excision revealed a basaloid appearance with angulated, hyperchromatic nuclei and scant, clear to eosinophilic cytoplasm. The tumor cells showed a perineural affinity. There were no features of distant metastasis. What is the most relevant prognostic marker in the patient?

1.Brain-derived neurotrophic factor
2.Hematogenous spread
3.Negative tumor margin
4.Mutation

Also comment on the diagnosis of the tumour ?

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