Get all clinically integrated questions in the GT - simulating the NEET/NEXT exam.  Biochem Question contributed by Dr. Reshma/ Dr Bala.

A 44-year-old woman presents to the emergency department because of fever, chills, and severe right flank pain. The patient states that she feels a burning sensation when she urinates. Her temperature is 39.8 C. Physical examination shows flank tenderness. Urinalysis shows a gram-negative rod. The patient is started on a drug that inhibits DNA replication. Which one of the following is the result of the enzyme activity inhibited by this drug?

1.Unwinding the double-helix structure of DNA by breaking hydrogen bonds
2. Stabilizing the unwound DNA, preventing it from forming into secondary structures
3.Relaxing DNA supercoils
4.Adding short strands of RNA primers onto the DNA template

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