Myelodysplastic / myeloproliferative neoplasm with ring sideroblasts and thrombocytosis is most frequently associated with alterations of which pair of genes?

1. ABL1 and CALR
2. ASXL1 and KRAS
3. SETBP1 and TP53
4. SF3B1 and JAK2
5. TET2 and FLT3

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