A 49-year-old man has complained of “heartburn” after meals for the past decade. There are no remarkable findings on physical examination. Upper gastrointestinal endoscopy is performed, and an esophageal biopsy specimen is taken from an erythematous area of velvety mucosa just above the gastroesophageal junction. Microscopically, the mucosa shows columnar metaplasia with goblet cells. Which of the following is correct regarding the disease?
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