Published on Mar 14, 2023
Not everything is CML

Leukemoid Reaction:

Definition of Leukemoid Reaction

  1. If there is a persistent increase in the neutrophils, reactive and excessive leucocytosis with a count of 30,000 to 50,000 / µL, with immature and mature white cells in the peripheral blood smear is called Leukemoid reaction. Sometimes lymphocytic reactions may be seen.
  2. This is not a primary marrow disorder, and this is due to secondary infections.
  3. The count varies from 50,000 to 100,000/cmm. With the presence of immature cells.
  4. Extremely elevated counts >100,000/cmm are more suggestive of the myeloproliferative process, with some exceptions.

Types of leukemoid reaction:

  1. Neutrophilic reaction.
  2. Lymphocytic reaction.
  3. Monocytic reaction.

Significance of leukemoid reaction

  1. This term is used to differentiate between leucocytosis and leukemia.
  2. In leukocytosis or neutrophilia, there is an increase in the count from 10,000 to 25,000 / µL (microliter).


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