PTLD complicates solid organ or bone marrow transplantation in 1% to 10% of cases. B-cell proliferations account for 95% of cases; the others are T-cell lymphomas. PTLD encompasses at least three clinicopathologic forms:

• Plasmacytic hyperplasia or infectious mononucleosis-like PTLD occurs in children and young adults early after transplantation, involving lymph nodes and tonsils. It resolves with reduction in immunosuppression.
• Polymorphic PTLD is more aggressive and consists of clonal growth of a mixed, pleomorphic population of lymphocytes, immunoblasts, and plasma  cells that efface lymph node architecture.
• Monomorphic PTLD is a lymphoma, usually with the features of diffuse large B-cell lymphoma

EBV is detected in 80% to 85% of all PTLD cases.

PTLD is being increasingly recognised in these days with more transplant recipients  -  Get up to date changes in medicine. Added to Revision Series - Subscribe here today