Histology of the Stomach

Gastric pits open on the surface of the mucosa and are connected to tubular gastric glands at their base. The neck is the place where the gastric glands and gastric pits join and the mucosal neck cells at this location continually divide to replace the cells that are lost. 

Gastric Secretory Cells

1. Parietal cells – secrete hydrochloric acid and intrinsic factor. Intrinsic factor is necessary for absorption of vitamin B 12.
2. Chief cells – secrete pepsinogen that is converted to the active proteolytic enzyme pepsin by the acids of the stomach.
3. Enteroendocrine cells – G cells produce the hormone gastrin that stimulates gastric juice secretion and gastric motility.

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