Published on Oct 16, 2020
Robbins Review Vignettes

A 49-year-old woman has been bothered for at least 20 years by recurring skin lesions that are most prominent over the elbows and knees and also sometimes on the scalp and lumbosacral area. These skin lesions are silvery to salmon-colored 1- to 4-cm plaques with scaling. The lesions seem to form more readily at sites of minor trauma, such as a superficial abrasion. She has had increasing pain in her left hand and in her hips, more prominent on the left, over the past 2 years. On physical examination, she has yellow-brown discoloration with pitting of the fingernails. The distal interphalangeal joints of digits two and three of the left hand are slightly swollen and tender. There is minimal reduction in left hip mobility and no swelling or warmth to the touch. A radiograph of the left hip shows minimal joint space narrowing and surface erosion. Bone density is not markedly reduced. During the next 10 years, the joint pain persists, but there is no joint destruction or deformity. She continues to have the same skin lesions. Which of the following is most likely to be seen on biopsy of these skin lesions?

  • Bandlike upper dermal infiltrate of lymphocytes
  • Epidermal spongiosis with dermal edema and eosinophils
  • Focal keratinocyte apoptosis
  • Hyperkeratosis with parakeratosis and elongated rete ridges


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