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A 70-year-old man with chronic heart failure underwent heart transplantation one month back. He currently has symptoms of dyspnea, fatigue, orthopnea, and paroxysmal nocturnal dyspnea. His pulse rate is 100/min, blood pressure is 140/90mm of Hg, and has bilateral pitting edema. The patient is currently on tacrolimus and mycophenolate mofetil. An endomyocardial biopsy is done, and histopathology shows a mononuclear inflammatory response infiltrating myocardial tissue with predominant lymphocytic cells. Which of the following is the most likely diagnosis?

1.Acute rejection
2.Hyperacute rejection
3.chronic rejection
4.Graft vs host disease

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