Published on Dec 30, 2020
Robbins Review Vignettes

A 65-year-old male with a past medical history of hypertension and hyperlipidemia presents to the hospital complaining of fatigue and abdominal fullness. He states that he had a recent dental procedure with persistent gingival bleeding, but he did not think much of it at the time. On physical examination, he is found to have splenomegaly. His examination reveals a temperature of 98.8 F (37.1 C), a blood pressure of 100/62 mmHg, a heart rate of 92 beats/min, and a respiratory rate of 18/min. Laboratory workup shows an elevated acid phosphatase that, when oxidized, turned into purple color. Which of the following cells would characteristically be seen in his blood smear?

Hairy cell leukemia: abnormal B cells look "hairy" under a microscope because of radial projections from their surface.

1.Hairy cells
2.Smudge cells
3.Myeloblasts with Auer rods
4.Reed-Sternberg cells


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