Last question answer - Hairy cell

A 40-year-old chronic alcoholic with no other medical history died after an alcohol-related seizure, in which he fell down the stairs at his house and fractured his neck. An autopsy is performed that reveals a diffusely golden-yellow discolored liver. Microscopic examination of the liver reveals almost every hepatocyte to be filled with one large vacuole or a few smaller vacuoles. Which of the following mechanisms most likely caused this intracellular inclusion?

1.  Abnormal metabolism
2. A defect in protein folding
3. The lack of an enzyme
4.  Ingestion of indigestible material

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