Published on Oct 6, 2020
Robbins Review Vignettes

A 19-year-old woman, G 2, P 1, has a screening ultrasound at 20 weeks’ gestation that shows no abnormalities. However, premature labor leads to an emergent vaginal delivery at 31 weeks. Soon after birth, the neonate develops respiratory distress requiring intubation with positive pressure ventilation. Which of the following prenatal diagnostic tests could have best predicted this neonate’s respiratory distress?

  • Maternal serum α-fetoprotein determination
  • Phospholipid analysis of amniotic fluid
  • Chromosomal analysis
  • Coombs test on cord blood

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