Published on Oct 12, 2020
Von Willebrand Disease
Vwf Multimer anaylsis
- Types 1 and 3 are due to a partial or complete deficiency of VWF
- Type 2 variants are due to specific functional defects in VWF. In type 2A VWD, there is an absence of high and medium molecular weight multimers
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| VWD Type | Multimer Analysis |
|---|---|
| 1 | All multimers are present including high molecular weight [HMW] forms but all are present in reduced concentration |
| 2A | Absence of large and intermediate forms |
| 2B Platelet-type VWD | Absence of large forms Platelet-type VWD shows similar results to 2B VWD with a loss of the HMW multimers |
| 2M | All sizes present |
| 2N | All sizes present |
| 3 | Absent multimers as no VWF |
| VWD Vicenza | Ultra-large VWF multimers present |
