40 year old men came with complaints of flushing. Hb 20g%. He was not affordable to do mutation studies. The patient underwent a bone marrow biopsy which shows increased in megakaryocytic lineage, rest normal. His EPO levels are normal. Can we label the patient to be suffering from Polycythemia Rubra Vera? #reinforce #criteria - Subscribe here today to learn pathology and reinforce with clinical examples !
Hello Everyone, We are almost nearing the end of the year.,Year which was surrounded mostly by negativity, Year where nothing has gone as planned,Year which procrastinated ! Yet we are all here, trying to push ourself every single day in our own domains believing that the next day will be always good.! That's life, with so much of positivity - and you are positive, every single person here in the earth is always hopeful. Every person plans the next day before sleep - I have to do this in the morning, these are the routine at work, these are things to be completed and meetings to attends... so on. Sometimes your study plan doesn't work, you get un-wantedly depressed. It has not happened that's all right, we shall correct it today ! Simple. I will put a little bit of extra effort and make today count is our promise for the day. ! - Finish your backlog videos.What big is going to happen - After all we have lived and we are going to finish the famous 20-20. Still we are all here, in half sleep looking at the screen and smiling to ourselves, which proves the fact - whatever may happen we are still the same "Stupid Us". No corona or no 2020 can stop us smiling, similarly nothing can stop you from winning !A very good morning..
PTEN: encodes a lipid phosphatase that is an important negative regulator of PI3K/AKT signaling. Germline loss-of-function mutations cause Cowden syndrome, an autosomal dominant disorder associated with a high risk of breast and endometrial carcinoma. Biallelic loss of function common in diverse cancers. Let's Relearn Conceptually - Subscribe here today to get access to revision series. !
For regular batch we will be starting systemic pathology from today. We shall be going in the order of Robbins. We shall discuss and correlate findings and pathogenesis from General Path and extrapolate it to patients. ! A basic understanding of Endothelium as portrayed below - Lets see what will happen when it goes wrong. Enrol here - regular batch. Revision Batch we shall continue with Neoplasia - Into the Molecular Hallmarks today ! - Subscribe here today to revise more efficientlyA
Ehlers-Danlos syndrome (EDS) is a group of inherited connective tissue diseases that have in common a defect in collagen structure or synthesis. There are a number of variants with different modes of inheritance. Kyphoscoliotic EDS: autosomal recessive form Vascular variant EDS: autosomal dominant form that causes rupture of vessels and bowel wallClassical EDS: autosomal dominant form that causes a type V collagen defect; patients have a normal lifespan Let's Relearn Pathology ! - Neoplasia chapter starts ! - Subscribe here today to get access
#somethingunique #exceptionCystic fibrosis seems to break 2 rules of genetics: Inheritance is autosomal recessive, even though the affected protein is a receptor protein. The clinical manifestations vary widely, which is more characteristic of autosomal dominant disorders. (Variable Expressivity)Relearn Pathology - Subscribe here today and start Neoplasia from 8 pm today !!
MYH9-Related Disorders - AD InheritanceMYH9-related disorders (MYH9RD) are characterized by large platelets and thrombocytopenia, both of which are present from birth.Epstein syndromeFechtner syndromeMay-Hegglin anomalySebastian syndromeRe-learn Pathology - Finish your backlogs today - Let's start a fresh start with neoplasia tomorrow ! - Subscribe here today
Neoplasia is one of the interesting chapters and with the current scenario of cancer becoming one of the leading causes of mortality worldwide, it's important to know understand the basics of cancer for future practical application as well ! So lets finish it in the coming week !December 20 - Introduction and cell cycleDecember 21 - Protooncogene and Tumour Suppressor genesDecember 22 - Apoptosis & Immunity and cancerDecember 23 - Metastasis and Carcinogens December 24 - Paraneoplastic Syndrome & PatternsDecember 25 - Infancy and InfectionsSubscribe here today - Let's Relearn Pathology ! You will get access to all the missed videos and tests, valid till May 2021
Wiskott-Aldrich syndromeX-linked recessive disease with mutation in the gene for Wiskott-Aldrich syndrome protein (WASP). The disease has a clinical triad of recurrent infections, severe thrombocytopenia, and eczema (chronic spongiform dermatitis).Treatment is hematopoietic stem cell transplantationSubscribe here today and lets interact and learn more ! #relearnpatho !
A Birds Eye View of Immunodeficiency disorder.We will be finishing immunology by today. From Tomorrow - Revision Batch will have NEOPLASIA. - Subscribe here todayRegular Batch - From Monday will be starting Systemic Pathology. Regular Batch - Subscribe here today